Promoting natural killer cell functions by recombinant immunoligands mimicking an induced self phenotype
نویسندگان
چکیده
Immunoligands for stimulatory natural killer (NK)-cell receptors can be targeted to the surface of malignant cells by fusing them to antibody fragments. Mimicking an "induced-self" phenotype, such recombinant immunoligands signal danger, trigger NK-cell cytotoxicity and synergistically enhance antibody-dependent cellular cytotoxicity. These findings may be translated into novel immunotherapeutic approaches against cancer.
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عنوان ژورنال:
دوره 2 شماره
صفحات -
تاریخ انتشار 2013